Irwin arias md biography

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I believe it was held at the Drake Hotel. Wow.

This introduced us to this whole area of polarization.

If you're a physician, the requirements to be certified in any given area, you know, they keep adding years and years on, it becomes impossible. All this information is just fascinating. And he said, "My name is John Enders, and I want you to keep in touch with me." A few years later, John Enders won the Nobel prize, or shared in it, for the discovery of polio virus.

And then it turns out of course that it's polarization is very complicated. It met twice a week for two-hour sessions. After a brief and uneventful naval career, I returned to college and graduated from Harvard in 1946, officially in the class of 1947. My friend Eddie and I were studying light transmission in plastics.

It wasn't just that the transporter didn't get to the apical membrane, it's that the cell was no longer polarized. I've never seen the word polarization used in a liver biopsy report in all my career, nor have my other colleagues. And at the end of the fifth year, I was given another choice. And I think it was largely his influence that I received an acceptance letter to the state university of New York in Brooklyn.

At the end of the second year, I was totally frustrated.

Somebody once said that it's more likely the academic physician who knows what the questions are, and it's the basic scientist who knows the answers, but they don't communicate. And that has been a great experience. You were at Tufts for a goodly period of time, and then when did you transfer to NIH and begin to spend a full time here?

Arias: Yeah, I was at Tufts for what, 18 years, I think?

I have been fortunate to have a list of mentors in science and in medicine that have all had profound influences not only on work but life and the way you think, for which I am very grateful.

At any rate, we took the assay back, modified it for bilirubin, and we worked out on enzymatic assay for an enzyme called UDP glucuronyl transferase, which transfers the glucuronic acid from a donor molecule, which had been discovered by a Scottish colleague, Geoffrey Dutton, from that donor molecule to bilirubin, and that enzyme is only found in the liver.

And at the same time had the support and working in Jennifer's domain. The whole apical membrane structure didn't occur.