Johannes andreas grib fibiger ujep

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They got married on 4 August 1894. C; Gluud, C. (1998). "The controlled clinical trial turns 100 years: Fibiger's trial of serum treatment of diphtheria". BMJ 317 (7167): 1243–1245. doi:10.1136/bmj.317.7167.1243. PMID 9794873. 

  • ↑ 7.07.1Fibiger, J. (1919). "On Spiroptera carcinomata and their relation to true malignant tumors; with some remarks on cancer age". The Journal of Cancer Research 4 (4): 367–387. doi:10.1158/jcr.1919.367. 
  • ↑Fibiger, J.; Ditlevsen, H. (1914). "Contributions to the biology and morphology of Spiroptera (Gongylonema) neoplastica n.

    K. (1925). "Experimental production of malignant growths by simple chemicals". The Journal of Cancer Research 9 (1): 135–147. doi:10.1158/jcr.1925.135. 

  • ↑Kuper, H.; Adami, H.-O.; Trichopoulos, D. (2000). "Infections as a major preventable cause of human cancer". Journal of Internal Medicine 248 (3): 171–183. doi:10.1046/j.1365-2796.2000.00742.x. PMID 10971784. 
  • ↑"A challenged Nobel Prize: Johannes Fibiger, 1926". Hist Sci Med 31 (1): 87–95. 1997. PMID 11625107. 
  • ↑Anon (2014). "Johannes Fibiger – Nominations". Nobel Media AB. https://www.nobelprize.org/nobel_prizes/medicine/laureates/1926/fibiger-nomination.html. 
  • ↑Foulerton, Alex.

    He was the second son of Christian Ludvig Wilhelm Fibiger and Elfride Fibiger (née Müller). C. (1935). "Spiroptera cancer and diet deficiency". Journal of Pathology and Bacteriology 40 (1): 198–199. 

  • ↑Cramer, W. (1937). "Papillomatosis in the forestomach of the rat and its bearing on the work of Fibiger". The American Journal of Cancer 31 (4): 537–555. doi:10.1158/ajc.1937.537. 
  • ↑Hitchcock, Claude R.; Bell, E.

    Fibiger had been suffering from colon cancer, and a month after he received his Nobel Prize, he died of heart attack on 30 January 1928 due to his worsening cancer. He also served as Principal of the Laboratory of Clinical Bacteriology of the Army from 1890 to 1905), and Director of the Central Laboratory of the Army and Consultant Physician to the Army Medical Service in 1905.[5]

    Fibiger died of cardiac arrest in Copenhagen on 30 January 1928.[5]

    Contributions

    Diphtheria research

    Fibiger's doctoral research was on diphtheria.

    Later he furthered his studies at the University of Berlin, where he was a disciple of Robert Koch and Emil Adolf von Behring, working as a professor of pathological anatomy. Vitus disease" or "dance of Saint Vitus", chorea sancti viti, "corea...

    Camilo Jose Cela

    Camilo José Cela y Trulock was a Spanish writer.

    Tumours and cancer produced by Fibiger were due to vitamin A deficiency.

    johannes andreas grib fibiger ujep

    • Category: Nobel laureates in Physiology or Medicine

    .

    This pioneering improvement in methodology, combined with a large number of patients and rigorous planning, conduct, and reporting, makes the trial a milestone in the history of clinical trials.[6]

    Cancer and parasitology research

    While studying tuberculosis in lab rats, Fibiger found tumors in some wild rats collected from Dorpat (officially Tartu, now in Estonia) in 1907.

    They concluded that Fibiger probably had mistaken metaplasia (a non-cancerous tumour) with malignant neoplasia (true cancer).[23] In 1937, W. Cramer experimentally showed that Fibiger's tumour were not cancerous.[24] The final disproof was shown by Claude R. Hitchcock and E. T. Bell. His mother established there the first cooking school, the Copenhagen Cooking School.

    Further more, his experimental method provided researchers with a means of producing cancer in the laboratory and anticipated investigation of specific carcinogenic agents and the precise way in which they acted. In 1926, he was nominated for the Nobel Prize in Physiology or Medicine along with Katsusaburo Yamagiwa, who had experimentally induced carcinomas by painting crude coal tar on the inner surface of rabbit ears in 1915.

    His research method on diphtheria is regarded as the origin of an important research methodology in medicine known as controlled clinical trial.[3]

    Biography

    Fibiger was born in Silkeborg, Midtjylland, Denmark.

    Fibiger was married to Mathilde Fibiger (1863-1954). Gastroenterol. 33 (3): 177–9. September 2001. doi:10.1097/00004836-200109000-00001. PMID 11500602. 

  • Raju, T N (1998). "The Nobel chronicles.

    T. (1952). "Studies on the nematode parasite, Gongylonema Neoplasticum (Spiroptera Neoplasticum), and avitaminosis a in the forestomach of rats: Comparison with Fibiger's results". Journal of the National Cancer Institute 12 (6): 1345–1387. doi:10.1093/jnci/12.6.1345. PMID 14939031. 

  • ↑"Katsusaburo Yamagiwa (1863–1930)". CA: A Cancer Journal for Clinicians 27 (3): 172–173. 1977. doi:10.3322/canjclin.27.3.172. PMID 406017. "Yamagiwa, then Director of the Department of Pathology at Tokyo Imperial University Medical School, had theorized that repetition or continuation of chronic irritation caused precancerous alterations in previously normal epithelium.

    His discovery was considered "the greatest contribution to experimental medicine" at the time.[2] In 1926, he was nominated for the Nobel Prize in Physiology or Medicine along with Katsusaburo Yamagiwa, who had experimentally induced carcinoma by painting crude coal tar on the inner surface of rabbits' ears in 1915.

    In 1918, they argued that the cancerous tumours produced in Fibiger's experiments were similar to non-cancerous tumours. Within a decade, Keller and associates extracted a highly potent carcinogenic hydrocarbon from coal tar.

    He studied at the University of Copenhagen, where he obtained his degree in 1890. In 1926, he received two nominations along with Katsusaburo Yamagiwa.[15] Folke Henschen and Hilding Bergstrand were appointed by the Nobel Committee as assessors.